Preferred Label : Engineered IL-12 Prodrug WTX-330;
NCIt synonyms : IL-12 INDUKINE WTX-330;
NCIt definition : An engineered, prodrug form of the human cytokine interleukin-12 (IL-12), composed
of wild-type IL-12 linked to a high affinity blockade element via a tumor protease-sensitive
linker, and a half-life extension domain, with potential immunomodulatory and antineoplastic
activities. Upon administration of engineered IL-12 prodrug WTX-330, IL-12 is bound
to the blockade element and pharmacologically inactive. Upon proteolytic cleavage
in the tumor microenvironment (TME), active IL-12 is released. IL-12 activates the
immune system by promoting the secretion of interferon-gamma (IFN-g) and activating
CD8 T-cells, CD4 T-cells and natural killer cells (NKs). The activation and expansion
of these immune cells mediate cytolytic immune responses against tumor cells, thereby
killing tumor cells and inhibiting tumor cell proliferation. The selective activation
in the TME enhances the IL-12-mediated cytolytic responses against tumor cells while
sparing the unwanted effects of systemic, peripheral immune activation. The inclusion
of the half-life extension domain prolongs the agent's exposure in the tumor.;
Molecule name : WTX 330; WTX-330;
NCI Metathesaurus CUI : CL1912923;
Origin ID : C192698;
UMLS CUI : C5785377;
Semantic type(s)
- concept_is_in_subset
