Preferred Label : KRAS G12D Inhibitor HRS-4642;
NCIt definition : An inhibitor of the oncogenic KRAS substitution mutation G12D, with potential antineoplastic
activity. Upon administration, KRAS G12D inhibitor HRS-4642 specifically targets and
binds to KRAS G12D. This prevents KRAS G12D-mediated signaling and activation of downstream
survival pathways. This leads to an inhibition of the growth of tumor cells that overexpress
KRAS G12D. KRAS, a member of the RAS family of oncogenes, serves an important role
in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive
signal transduction leading to tumor cell proliferation, invasion, and metastasis.;
Molecule name : HRS 4642; HRS-4642;
NCI Metathesaurus CUI : CL1912585;
Origin ID : C192673;
UMLS CUI : C5785368;
Semantic type(s)
- concept_is_in_subset
- has_target
