NCIt definition : Progastrin (80 aa, 9 kDa) is encoded by the human GAST gene. This protein is involved
in the secretion of digestive factors by the gastrointestinal system. Circulating
progastrin is associated with tumorigenesis.;
NCIt note : Progastrin is produced by removal of the 21 amino acid signal peptide from the 101
amino acid (prepro)gastrin protein. When expressed intracellularly in the gastrointestinal
system, this 80 amino acid form is a precursor to the hormonally active forms of gastrin;
however, this proform also can be secreted into the bloodstream of individuals with
various cancers, where it promotes angiogenesis and cell survival during tumor initiation
and progression.;
OMIM relation