Preferred Label : Autologous UV-oHSV2-activated Peripheral Blood Mononuclear Cells;
NCIt synonyms : Autologous VAK Immune Cells; Autologous Ultraviolet Inactivated Oncolytic Herpes Simplex Virus Type 2-activated
Peripheral Blood Mononuclear Cells; Autologous UV-oHSV2-activated PBMCs; Autologous Virus-activated Killer Immune Cells;
NCIt definition : A preparation of autologous peripheral blood mononuclear cells (PBMCs) activated ex
vivo by ultraviolet-inactivated oncolytic herpes simplex virus type 2 (UV-oHSV2),
with potential immunomodulating and antineoplastic activities. Upon reintroduction
of the autologous UV-oHSV2-activated PBMCs into the patient, the activated immune
cells kill tumor cells. Ex vivo UV-oHSV2 treatment induces natural killer (NK) cell
proliferation and the secretion of interferon-gamma (IFNg). This leads to immune-mediated
tumor cell death and the inhibition of tumor cell proliferation.;
NCI Metathesaurus CUI : CL1912590;
Origin ID : C192652;
UMLS CUI : C5785355;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
