Preferred Label : Anti-CD32B Monoclonal Antibody BI-1607;
NCIt synonyms : Anti-FcgRIIB Monoclonal Antibody BI-1607;
NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody targeting Fc gamma receptor IIB
(FcgRIIB; CD32B), with potential immunomodulatory- and antineoplastic-enhancing activities.
Upon administration, anti-CD32B monoclonal antibody BI-1607 selectively targets and
binds to CD32B, an inhibitory Fc gamma receptor (FcgR) protein expressed on immune
cells, including macrophages. This prevents both the binding of human epidermal growth
factor receptor 2 (HER2; ErbB2; HER-2)-targeting monoclonal antibodies to CD32B, and
CD32B-mediated inhibition of the activation of macrophages. By blocking CD32B, BI-1607
may enhance the activity of anti-HER2 monoclonal antibodies. CD32B, an inhibitory
member of the FcgR family, is implicated in immune cell desensitization and tumor
cell resistance.;
Molecule name : BI-1607; BI 1607;
NCI Metathesaurus CUI : CL1912586;
Origin ID : C192648;
UMLS CUI : C5785351;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
