Preferred Label : Anti-TCR Vb6/Vb10/IL-2 Antibody Fusion Protein STAR0602;
NCIt synonyms : Anti-TCR Vb6/Vb10/IL-2 Bifunctional Antibody-fusion Molecule STAR0602; Anti-TCR Vb/IL-2 Bispecific Antibody Fusion Protein STAR0602;
NCIt definition : A bifunctional antibody fusion protein composed of an agonist antibody targeting the
variable (V) beta 6 (Vb6) and beta 10 (Vb10) regions of the T cell receptor (TCR)
and fused to the cytokine interleukin-2 (IL-2), with potential immunostimulating and
antineoplastic activities. Upon administration, anti-TCR Vb6/Vb10/IL-2 antibody fusion
protein STAR0602 selectively targets and binds to the Vb6 and Vb10 regions of the
TCR expressed on a subset of alpha/beta T-cells, thereby activating and expanding
these alpha/beta T-cells. This promotes T-cell-mediated immune responses against tumor
cells. IL-2 targets and binds to the IL-2 receptor IL2R and activates IL-2/IL-2R-mediated
signaling, which further activates cytotoxic T-lymphocytes (CTLs) and natural killer
(NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma
(IFNg) and transforming growth factor-beta (TGFb). This further enhances T-cell-mediated
cytotoxic immune responses against tumor cells. Alpha/beta T-cells play an important
role in the adaptive immune response.;
Molecule name : STAR-0602; STAR 0602;
NCI Metathesaurus CUI : CL1905546;
Origin ID : C192208;
UMLS CUI : C5784979;
Semantic type(s)
- concept_is_in_subset
