Preferred Label : TLR Agonist Decoy20;
NCIt synonyms : Toll-like Receptor Agonist Decoy20;
NCIt definition : A multi-targeted toll-like receptor (TLR) agonist, with potential immunomodulating
and antineoplastic activities. Upon administration, TLR agonist Decoy20 activates
one or more not yet disclosed TLRs expressed on various immune cells, such as macrophages
and plasmacytoid dendritic cells (pDCs), which results in their stimulation, the production
of certain pro-inflammatory cytokines, and the upregulation of co-stimulatory molecules.
This may lead to enhanced T- and B-cell stimulatory responses, cytotoxic T-cell proliferation,
a T-helper 1 (Th1) immune response, and immune-mediated tumor cell killing. TLRs are
transmembrane receptors that recognize structurally conserved microbial molecules
such as bacterial cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides,
lipoarabinomannan and flagellin, among others. Immune responses stimulated by TLR
activation may result in innate and adaptive immune-mediated tumor cell killing.;
Molecule name : Decoy 20; Decoy-20;
NCI Metathesaurus CUI : CL1905580;
Origin ID : C192168;
UMLS CUI : C5784954;
Semantic type(s)
- concept_is_in_subset
