Preferred Label : Allogeneic Polymer-encapsulated IL-2-secreting Retinal Pigmented Epithelial Cells
AVB-001;
NCIt synonyms : Allogeneic Polymer-encapsulated IL-2-secreting RPE Cells AVB-001;
NCIt definition : A preparation of polymer-encapsulated cells, obtained from the human immortalized
retinal pigment epithelia (RPE) cell line ARPE-19, that have been genetically engineered
to express the human cytokine interleukin-2 (IL-2; IL2), with potential immunomodulatory
and antineoplastic activities. Upon intraperitoneal administration, allogeneic polymer-encapsulated
IL-2-secreting RPE cells AVB-001 produces IL-2 locally, which binds to the IL-2 receptor
(IL-2R) and activates IL-2/IL-2R-mediated signaling. This activates cytotoxic T-lymphocytes
(CTLs) and natural killer (NK) cells and induces expression of certain cytotoxic cytokines,
such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). This leads
to T-cell-mediated cytotoxic immune responses against tumor cells and inhibition of
tumor cell proliferation. The local delivery of AVB-001 reduces systemic toxicities,
and the polymer encapsulation allows for longer half-life.;
Molecule name : AVB-001; AVB 001;
NCI Metathesaurus CUI : CL1905412;
Origin ID : C192001;
UMLS CUI : C5784823;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
