NCIt synonyms : TRAP; CVAK90; NKTL; N-Terminal Kinase-Like Gene; SCY1-Like Gene; SCY1, S. cerevisiae, Homolog of Gene; SCY1-Like 1 (S. cerevisiae) Gene; SCAR21; SCY1 Like Pseudokinase 1 wt Allele; MGC78454; Likely Ortholog of Mouse N-Terminal Kinase-Like Protein Gene; Telomerase Transcriptional Elements-Interacting Factor Gene; HT019; TEIF; SCY1-Like, Kinase-Like 1 Gene; P105; NTKL; GKLP; TAPK;
NCIt definition : Human SCYL1 wild-type allele is located in the vicinity of 11q13.1 and is approximately
14 kb in length. This allele, which encodes N-terminal kinase-like protein, is involved
in regulation of retrograde protein traffic between the Golgi apparatus and the endoplasmic
reticulum. One transcript may also be involved in transcriptional regulation. Mutation
of the gene is associated with autosomal recessive spinocerebellar ataxia 21, which
is also called cholestasis, acute liver failure, and neurodegeneration (CALFAN) syndrome.;