Preferred Label : Deceptive Imprinting;
NCIt definition : Refers to a mechanism leading to a fixed state of immunity that fails to adapt to
a changing pathogen and has lost the ability to discriminate antigen after the establishment
of a strong primary immune response.;
NCIt note : In HIV infections, the maintenance of the clonal profile of anti-HIV-1 antibodies
developed during the initial infection despite a subsequent emergence of viral variants.
It has been argued that deception of the immune response is caused by immunodominant
epitopes on viral variants or recombinant proteins that are selected to induce or
maintain the initial (imprinted) state. (from Kohler et al 1994 Immunol Today, 15:475);
Origin ID : C19131;
UMLS CUI : C1511739;
Semantic type(s)
- biological_process_has_initiator_process
