Preferred Label : Gonadotropin-releasing Hormone Analog;
NCIt synonyms : Luteinizing Hormone-Releasing Hormone Analog; GnRH Agonist; GnRH Analog; Gonadotropin-Releasing Hormone Analogue; LH-RH Analogs;
NCIt related terms : luteinizing hormone-releasing hormone agonist; LHRH Agonist; gonadotropin-releasing hormone agonist; LH-RH agonist;
NCIt definition : A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH),
with potential antineoplastic activity. Upon administration, GnRH analogue mimics
endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which
stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating
hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the
GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation.
This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males,
the inhibition of LH secretion prevents the production and release of testosterone
from Leydig cells in the testes and causes a significant decline in testosterone production
that is near the levels seen after castration. This may inhibit androgen receptor-positive
tumor progression. In females, this results in a decrease in estradiol production.
GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized
in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor
binding affinity than the endogenous form.;
Alternative definition : NCI-GLOSS: A substance that keeps the testicles and ovaries from making sex hormones
by blocking other hormones that are needed to make them. In men, gonadotropin-releasing
hormone agonists cause the testicles to stop making testosterone. In women, they cause
the ovaries to stop making estrogen and progesterone. Some gonadotropin-releasing
hormone agonists are used to treat prostate cancer. Also called GnRH agonist, LH-RH
agonist, and luteinizing hormone-releasing hormone agonist.;
Codes from synonyms : CDR0000533240; CDR0000046304; CDR0000306500;
Origin ID : C1910;
UMLS CUI : C1518041;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
