Preferred Label : Cell Membrane-anchored/CSV-targeted IL-12-expressing T-lymphocytes;
NCIt synonyms : attIL12-expressing T-cells; attIL12-T Cells; Cell Membrane-anchored/Tumor-targeted IL-12-expressing T-cells; attIL12 Armed T Cells;
NCIt definition : A preparation of T-lymphocytes engineered to express cell membrane-anchored and cell-surface
vimentin (CSV)-targeted interleukin-12 (IL-12), with potential immunostimulatory and
antineoplastic activities. Upon administration, the cell membrane-anchored/CSV-targeted
IL-12-expressing T-lymphocytes are directed to and induce selective toxicity in CSV-expressing
tumor cells. The cell membrane-anchored IL-12 cytokine promotes the secretion of interferon-gamma
(IFNg), activates natural killer cells (NKs), and induces cytotoxic T-lymphocyte (CTL)
responses against tumor cells locally, which may result in immune-mediated tumor cell
death and the inhibition of tumor cell proliferation. Vimentin, overexpressed in various
tumors, is associated with tumor growth and metastasis. Cell membrane-anchored IL-12
reduces the circulating levels of the inflammatory cytokine and the associated systemic
adverse effects.;
NCI Metathesaurus CUI : CL1799275;
Origin ID : C190860;
UMLS CUI : C5783961;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
