Preferred Label : Fc-IL-15 Prodrug Fusion Molecule ASKG315;
NCIt synonyms : Fc-IL-15 Prodrug Fusion Molecule ASKG215b;
NCIt definition : An engineered, prodrug form of the human endogenous cytokine interleukin-15 (IL-15),
composed of a mutated form of IL-15 fused to a Fc fragment and linked to a masking
moiety via a tumor protease-cleavable linker, with potential antineoplastic activity.
Upon administration of Fc-IL-15 prodrug fusion molecule ASKG315, IL-15 is bound to
the masking moiety and pharmacologically inactive. Upon proteolytic cleavage in the
tumor microenvironment (TME), active IL-15 is released. IL-15 stimulates the proliferation
of natural killer (NK) cells and memory CD8 T-cells. The memory T-cells enhance the
secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the
immune response against tumor cells. This may increase tumor cell killing and decrease
tumor cell proliferation. IL-15 regulates CD8 T and NK cell development, activation
and proliferation. The selective activation in the TME enhances the IL-15-mediated
cytolytic responses against tumor cells while sparing the unwanted effects of systemic,
peripheral immune activation.;
Molecule name : ASKG 215b; ASKG 315; ASKG-315; ASKG215beta; ASKG-215b;
NCI Metathesaurus CUI : CL1799292;
Origin ID : C190819;
UMLS CUI : C5783947;
Semantic type(s)
- concept_is_in_subset
