Anti-KLRG1 Monoclonal Antibody ABC008

Preferred Label : Anti-KLRG1 Monoclonal Antibody ABC008;

NCIt definition : A humanized, afucosylated monoclonal antibody directed against killer cell lectin-like receptor G1 (KLRG1), with potential immunomodulatory activity. Upon administration, anti-KLRG1 monoclonal antibody ABC008 targets and binds to KLRG1 expressed on highly differentiated effector CD8 cytotoxic T-cells, and selectively depletes these highly differentiated cytotoxic T-cells while sparing other immune cells. This prevents the killing of cells by these highly differentiated cytotoxic T-cells in certain autoimmune diseases, such as the destruction of muscle tissue in inclusion body myositis, and the destruction of neutrophils and red blood cell precursors in T-cell large granular lymphocytic leukemia (T-LGLL).;

Molecule name : ABC 008; ABC-008;

NCI Metathesaurus CUI : CL1799380;

Details

Origin ID

C190733;

UMLS CUI

C5783890;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Killer Cell Lectin-Like Receptor Subfamily G Member 1 [NCIt concept]

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