Preferred Label : CARD11-BCL10-MALT1 Complex Inhibitor XL114;
NCIt synonyms : CARMA1-BCL10-MALT1 Pathway Inhibitor XL114; CARD11-BCL10-MALT1 Pathway Inhibitor XL114;
NCIt definition : An orally bioavailable inhibitor of the caspase recruitment domain-containing protein
11 (CARD11; CARMA1)-B-cell lymphoma/leukemia 10 (BCL10)-mucosa-associated lymphoid
tissue lymphoma translocation protein 1 (MALT1) complex, with potential antineoplastic
activity. Upon oral administration, CARD11-BCL10-MALT1 complex inhibitor XL114 inhibits
the CARD11-BCL10-MALT1 complex and the CARD11-BCL10-MALT1 signaling pathway. This
prevents the proliferation of susceptible cancer cells. The CARD11-BCL10-MALT1 signaling
pathway promotes B- and T-cell lymphoma survival and proliferation.;
Molecule name : AUR-104; XL-114; XL 114; AUR 104;
NCI Metathesaurus CUI : CL1799364;
Origin ID : C190716;
UMLS CUI : C5783880;
Semantic type(s)
- concept_is_in_subset
