GNAQ/GNA11 Antagonist DYP688

Preferred Label : GNAQ/GNA11 Antagonist DYP688;

NCIt definition : An antagonist of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)/ guanine nucleotide-binding protein subunit alpha-11 (GNA11), with potential antineoplastic activity. Upon administration, GNAQ/GNA11 antagonist DYP688 inhibits the activity of GNAQ/GNA11 and prevents GNAQ/GNA11-mediated signaling. This may prevent proliferation in tumors overexpressing and/or harboring mutations of GNAQ/GNA11. GNAQ and GNA11 are involved in carcinogenesis and are mutated in certain melanomas.;

Molecule name : DYP-688; DYP 688;

NCI Metathesaurus CUI : CL1799078;

Details

Origin ID

C190696;

UMLS CUI

C5783865;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-11 [NCIt concept]

Keyword's position in hierarchy(ies) :

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