NCIt definition : A recombinant, fully human monoclonal antibody directed against the cell surface receptor
CD39 (cluster of differentiation 39; ectonucleoside triphosphate diphosphohydrolase-1;
NTPDase1; ENTPD1), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-CD39 monoclonal antibody JS019 specifically targets and
binds to the CD39 antigen, thereby preventing the conversion and degradation of adenosine
triphosphate (ATP) to adenosine monophosphate (AMP). This leads to an increase in
the extracellular levels of immunogenic ATP and a decrease in the levels of immunosuppressive
adenosine within the tumor microenvironment (TME). A high level of ATP increases pro-inflammatory
cytokine levels and promotes both T-cell proliferation and the stimulation of dendritic
and other myeloid-derived cells that are necessary for innate and adaptive immunity.
CD39, a cell surface ectonucleosidase, is upregulated on tumor cells as an immune
evasion strategy; blocking its action may improve anti-tumor immune responses.;
Semantic type(s)