Preferred Label : Darunavir/Ritonavir;
NCIt synonyms : Ritonavir/Darunavir; Darunavir-Ritonavir; DRV/r;
NCIt definition : A fixed combination of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease
nonpeptidic inhibitor, and ritonavir, a cytochrome P450 3A4 (CYP3A4) inhibitor, that
may be used to treat HIV-1 infection. Upon oral administration of darunavir/ritonavir,
darunavir selectively targets and binds to the active site of HIV-1 protease, and
inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits
the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells.
This inhibition leads to the production of immature, non-infectious viral proteins
that are unable to form mature virions, and prevents HIV replication. Ritonavir inhibits
CYP3A4, thereby limiting the metabolism of darunavir, which is a CYP3A4 substrate.
This leads to an increased concentration and half-life of darunavir as compared to
the administration of darunavir without ritonavir.;
NCI Metathesaurus CUI : CL1799098;
Origin ID : C190683;
UMLS CUI : C1976853;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
