Preferred Label : T-Cell Transformation;
NCIt definition : Morphologic alteration of small T lymphocytes in culture into large blast-like cells
able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins,
mitogens such as phytohemagglutinins, and by specific antigens. It may also occur
in vivo, as in graft rejection and chronic myelogenous leukemia, or the process that
a normal T lymphocyte goes through when induced by a pathologic agent such as human
T-lymphotropic virus 1 (HTLV-1) to become an adult T cell leukemia or other aggressive
malignancy where neoplastic T cells apparently use IL-2 as an autocrine growth factor.
(from Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, p.768);
Origin ID : C19054;
UMLS CUI : C1515136;
See also inter- (CISMeF)
- Semantic type(s)
- biological_process_is_part_of_process
