" /> Ulviprubart - CISMeF





Preferred Label : Ulviprubart;

NCIt synonyms : Anti-KLRG1 Monoclonal Antibody ABC-008; Anti-KLRG1 Monoclonal Antibody ABC008;

NCIt definition : A humanized, afucosylated monoclonal antibody directed against killer cell lectin-like receptor G1 (KLRG1), with potential immunomodulatory activity. Upon administration,ulviprubart targets and binds to KLRG1 expressed on highly differentiated effector CD8 cytotoxic T-cells, and selectively depletes these highly differentiated cytotoxic T-cells while sparing other immune cells. This prevents the killing of cells by these highly differentiated cytotoxic T-cells in certain autoimmune diseases, such as the destruction of muscle tissue in inclusion body myositis, and the destruction of neutrophils and red blood cell precursors in T-cell large granular lymphocytic leukemia (T-LGLL).;

UNII : QT44II3WZP;

CAS number : 2569434-60-0;

Molecule name : ABC 008; ABC-008;

NCI Metathesaurus CUI : CL1799216;

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Keyword's position in hierarchy(ies) : arborescence

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23/08/2025


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