NCIt definition : A humanized, afucosylated monoclonal antibody directed against killer cell lectin-like
receptor G1 (KLRG1), with potential immunomodulatory activity. Upon administration,ulviprubart
targets and binds to KLRG1 expressed on highly differentiated effector CD8 cytotoxic
T-cells, and selectively depletes these highly differentiated cytotoxic T-cells while
sparing other immune cells. This prevents the killing of cells by these highly differentiated
cytotoxic T-cells in certain autoimmune diseases, such as the destruction of muscle
tissue in inclusion body myositis, and the destruction of neutrophils and red blood
cell precursors in T-cell large granular lymphocytic leukemia (T-LGLL).;