Preferred Label : Bofutrelvir;
NCIt synonyms : 1H-Indole-2-carboxamide, N-((1S)-1-(cyclohexylmethyl)-2-(((1S)-1-formyl-2-((3S)-2-oxo-3-pyrrolidinyl)ethyl)amino)-2-oxoethyl)-; N-((S)-3-Cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)-propan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; Mpro Inhibitor 11A;
NCIt definition : A small molecule inhibitor of the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) main protease (Mpro; 3C-like protease; 3CL protease; 3CLpro; nsp5 protease),
with potential antiviral activity against SARS-CoV-2. Upon intravenous administration
or inhalation into the lungs, bofutrelvir selectively targets, binds to, and inhibits
the activity of SARS-CoV-2 Mpro. This inhibits the proteolytic cleavage of viral polyproteins,
thereby inhibiting the formation of viral proteins including helicase, single-stranded-RNA-binding
protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease
and exoribonuclease. This prevents viral transcription and replication. Bofutrelvir
may have antiviral activity in the brain.;
UNII : T5UX5SKK2S;
CAS number : 2103278-86-8;
Molecule name : DC402234; MPI-10; FB-2001; MPI 10; FB 2001;
NCI Metathesaurus CUI : CL1798911;
Origin ID : C190414;
UMLS CUI : C5783686;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
