Preferred Label : Lipid Nanoparticle Encapsulated Self-replicating RNA Encoding Human IL-12 JCXH-211;
NCIt synonyms : LNP Encapsulated srRNA Encoding Human IL-12 JCXH-211;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating self-replicating
RNA (srRNA) encoding human interleukin-12 (IL-12), with potential immunomodulatory
and antineoplastic activities. Upon intratumoral injection of LNP encapsulated srRNA
encoding human IL-12 JCXH-211, the LNPs bind to the plasma membrane of nearby tumor
cells and release srRNA encoding IL-12 into the tumor cells. The srRNA amplifies within
the tumor cells, and is translated by the cellular protein translation machinery to
produce IL-12, which is secreted into the local tumor microenvironment (TME). The
secretion of IL-12 activates the immune system by promoting the secretion of interferon-gamma
(IFN-g), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte
(CTL) responses, which may enhance immune-mediated destruction of tumor cells and
decrease tumor cell proliferation. In addition, the virus-based RNA replicon may trigger
anti-viral innate immune responses, further killing tumor cells.;
Molecule name : JCXH 211; JCXH-211;
NCI Metathesaurus CUI : CL1798941;
Origin ID : C190391;
UMLS CUI : C5783675;
Semantic type(s)
- concept_is_in_subset
