Preferred Label : C7R-expressing EBVSTs;
NCIt synonyms : C7R-expressing Epstein-Barr Virus-specific T-lymphocytes; C7R-expressing EBV-specific T-lymphocytes; C7R-EBV T-cells; C7R Modified EBV Specific T-Lymphocytes;
NCIt definition : A preparation of human Epstein-Barr virus (EBV)-specific T-lymphocytes (EBVSTs) that
have been genetically modified to express the constitutively active interleukin 7
(IL-7) receptor (C7R; IL-7R), with potential immunostimulating and antineoplastic
activities. Upon administration, the CR7-expressing EBVSTs specifically recognize
and bind EBV-infected tumor cells, resulting in tumor cell lysis. EBV, a ubiquitous
human herpes virus, is associated with various malignancies, specifically nasopharyngeal
carcinoma and lymphomas, including Hodgkin and non-Hodgkin. C7R triggers IL-7-mediated
signaling that promotes T-cell proliferation and survival. The enhanced T-cell survival
prolongs EBV-infected tumor cell killing and anti-tumor activity.;
NCI Metathesaurus CUI : CL1799032;
Origin ID : C190298;
UMLS CUI : C5783615;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
