NCIt definition : A humanized monoclonal antibody directed against the immune checkpoint protein butyrophilin
1A1 (BTN1A1), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, nelmastobart targets and binds to the extracellular domain of
human BTN1A1, which prevents the formation of the BTN1A1-galectin-9 (Gal9)-programmed
cell death protein 1 (PD-1) complex, and inhibits downstream signaling pathways. This
may restore immune function through the activation of T-cells and T-cell-mediated
immune responses against tumor cells. The BTN1A1-Gal9-PD-1 axis suppresses T-cell
receptor (TCR) signaling and T-cell activation. BTN1A1 does not bind to PD-1 directly
but interacts with PD-1 through Gal9. BTN1A1, a member of the butyrophilin superfamily
of immunomodulators, is upregulated in a variety of tumor cell types.;
Semantic type(s)