Preferred Label : Acetylglucosaminyltransferase V Inhibitor PhOx430;
NCIt synonyms : GnT-V Inhibitor PhOx430; N-Acetylglucosaminyltransferase V Inhibitor PhOx430;
NCIt definition : An inhibitor of the glycosyltransferase N-Acetylglucosaminyltransferase V (GnT-V),
with potential antineoplastic activity. Upon administration, GnT-V inhibitor PhOx430
targets, binds to and inhibits the activity of GnT-V, a glycosylation enzyme that
synthesizes the beta1, 6-GlcNAc branch in N-glycans. This inhibits the glycosylation
of tumor cells and downregulates cell surface receptors implicated in tumor cell growth
and metastasis. GnT-V and its product N-glycans, upregulated in various types of cancer
cells, are associated with cancer proliferation and metastasis.;
Molecule name : PhOx-430; PhOx 430;
NCI Metathesaurus CUI : CL1798790;
Origin ID : C190127;
UMLS CUI : C5783513;
Semantic type(s)
- concept_is_in_subset
