Preferred Label : Vensobafusp Alfa;
NCIt synonyms : Anti-C5 Monoclonal Antibody/FH SCR 1-5 Fusion Protein KP104; Anti-C5 Monoclonal Antibody/FH1-5 Fusion Protein KP104; Anti-C5 Monoclonal Antibody/Complement Factor H 1-5 Domain Fusion Protein KP104;
NCIt definition : A fusion protein composed of an engineered immunoglobulin G4 (IgG4) monoclonal antibody
directed against terminal complement protein C5 fused to the complement factor H 1-5
domain (FH1-5), with potential anti-inflammatory and immunomodulatory activities.
Upon administration of a vensobafusp alfa, the anti-C5 antibody moiety targets and
binds to terminal complement protein C5, thereby blocking the terminal complement
pathway of complement activation. The FH1-5 moiety inhibits complement C3b deposition,
thereby blocking the alternative pathway of complement activation. This inhibits complement-mediated
inflammation and cell lysis. Excessive complement activation plays a key role in various
inflammatory and autoimmune diseases, and leads to tissue destruction.;
UNII : G3PS38JMS8;
CAS number : 2724922-85-2;
Molecule name : KP1-04; KP1 04;
NCI Metathesaurus CUI : CL1798777;
Origin ID : C190117;
UMLS CUI : C5854891;
Semantic type(s)
- concept_is_in_subset
