Preferred Label : Dibotatug;
NCIt synonyms : Monoclonal Antibody DR-01;
NCIt definition : A human non-fucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against
the cell surface receptor and natural killer cell antigen CD94 (killer cell lectin-like
receptor D1; KLRD1), with potential immunomodulating and antineoplastic activities.
Upon administration, dibotatug targets and binds to CD94 expressed on CD94-expressing
tumor cells and induces fracticide via antibody-dependent cellular cytotoxicity (ADCC).
This depletes CD94-expressing tumor cells and may reduce tumor cell proliferation.
Also, dibotatug may modulate immune responses in certain autoimmune conditions. CD94,
a transmembrane receptor, is expressed on mature, cytotoxic lymphocytes such as healthy
natural killer (NK) cells and terminally differentiated CD8 T-cells. It is upregulated
on certain lymphomas and leukemias, such as large granular lymphocyte leukemia (LGLL)
cells.;
UNII : HBU6X8D6VB;
CAS number : 2842038-48-4;
Molecule name : DR 01; DR-01;
NCI Metathesaurus CUI : CL1798774;
Origin ID : C190114;
UMLS CUI : C5783502;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
