Preferred Label : Anti-CD19 Cord Blood-derived CAR-NK Cells;
NCIt synonyms : CB CAR NK Cells NK019; CB CAR-NK019; CAR-NK019; CB Anti-CD19 CAR NK Cells NK019;
NCIt definition : A preparation of cord blood (CB)-derived natural killer (NK) cells that have been
genetically modified and transduced with a lentiviral vector to express a chimeric
antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of
differentiation 19 (CD19), with potential immunomodulating and antineoplastic activities.
Upon administration, the anti-CD19 CB-derived CAR-NK cells recognize, bind to and
induce selective cytotoxicity in CD19-expressing tumor cells. CD19 is a B-cell specific
cell surface antigen overexpressed in B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL1798776;
Origin ID : C190112;
UMLS CUI : C5783500;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
