Preferred Label : Aminolevulinic Acid Intravenous Formulation SONALA-001;
NCIt synonyms : ALA Intravenous Formulation SONALA-001;
NCIt definition : An intravenous formulation of aminolevulinic acid (ALA), a metabolic precursor of
the photosensitizer protoporphyrin IX (PpIX), with potential antineoplastic activity
upon magnetic resonance-guided focused ultrasound (MRgFUS). Upon intravenous administration
of SONALA-001, ALA readily crosses the blood brain barrier (BBB) and accumulates intracellularly,
where ALA is metabolized to the photosensitizer PpIX by enzymes in the heme biosynthesis
pathway. Due to the distinct activity of these enzymes in tumor cells, there is a
higher accumulation of PpIX in tumor cells. Upon MRgFUS, the energy of ultrasound
produces light (sonoluminescence) within the brain and activates PpIX in tumor cells.
Ultrasound-activated PpIX catalyzes molecular oxygen to singlet oxygen, an intracellular
toxin, which can further react to form superoxide and hydroxyl radicals. This leads
to cellular cytotoxic effects.;
Molecule name : SONALA 001; SONALA-001;
NCI Metathesaurus CUI : CL1798822;
Origin ID : C190109;
UMLS CUI : C5783498;
Semantic type(s)
- concept_is_in_subset
