Preferred Label : Meropenem Trihydrate/Vaborbactam;
NCIt synonyms : Vaborbactam/Meropenem; Meropenem-Vaborbactam;
NCIt related terms : Vabomere; Meropenem/Vaborbactam;
NCIt definition : A fixed two-agent injectable combination of the trihydrate form of meropenem, a broad-spectrum
synthetic beta-lactam carbapenem antibiotic, and vaborbactam, a cyclic boronic acid
beta-lactamase inhibitor, with antibacterial activity against susceptible bacteria.
Upon administration of meropenem trihydrate/vaborbactam, meropenem binds to and inactivates
penicillin-binding proteins (PBPs) on the inner membrane of the bacterial cell wall,
thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial
cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and
results in the weakening of the bacterial cell wall and causes cell lysis. Vaborbactam
binds to and inhibits beta-lactamase, thereby inhibiting the breakdown of meropenem,
and increases the activity and therapeutic effect of meropenem.;
Drug name : Vabomere; Vaborem;
NCI Metathesaurus CUI : CL1798505;
Origin ID : C189976;
UMLS CUI : C4482910;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
