Preferred Label : Tozinameran/Famtozinameran;
NCIt synonyms : Tozinameran/Lipid Nanoparticle-encapsulated mRNA-based Omicron BA.4/BA.5 Bivalent
SARS-CoV-2 Vaccine; Famtozinameran/Tozinameran;
NCIt related terms : Pfizer/BioNTech COVID-19 Vaccine, Bivalent, US;
NCIt definition : A bivalent booster vaccine consisting of tozinameran, a lipid nanoparticle (LNP) encapsulating
a nucleoside modified messenger RNA (modRNA) encoding an optimized form of the full-length
viral spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
Wuhan-Hu-1 strain (Original), and famtozinameran, a LNP encapsulating a modRNA encoding
an optimized form of the full-length viral S protein of the SARS-CoV-2 Omicron variant
lineages BA.4 and BA.5 (Omicron BA.4/BA.5), with potential immunizing and anti-COVID-19
activities. Upon injection of famtozinameran/tozinameran, the LNPs bind to the plasma
membrane of nearby cells and release SARS-CoV-2 S protein mRNA into the cells. The
mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2
S protein. This may activate both humoral and cellular immune responses which may
result in protection against SARS-CoV-2 infection.;
NCI Metathesaurus CUI : CL1798504;
Origin ID : C189973;
UMLS CUI : C5708853;
Semantic type(s)
- concept_is_in_subset
