NCIt definition : A T-cell engaging bispecific antibody directed against both the tumor-associated antigen
(TAA) G-protein coupled receptor family C group 5 member D (GPRC5D) and the T-cell
surface antigen CD3, with potential antineoplastic activity. Upon administration,
forimtamig binds to both GPRC5D expressed on tumor cells and CD3 on T-cells. This
results in the cross-linking of T-cells and tumor cells and induces a potent cytotoxic
T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed
on certain tumors, such as multiple myeloma, while minimally expressed on normal,
healthy cells, and plays a key role in tumor cell proliferation.;
UNII : 1GK8Z1OT1R;
CAS number : 2649379-96-2;
Molecule name : RG-6234; RO-7425781; RO 7425781; RG 6234;
Semantic type(s)