Preferred Label : Allogeneic DNT Cells RC1012;
NCIt synonyms : Allo-DNT Cells RC1012; Bi-negative T-cells RC1012; CD3 CD4-CD8-T-cells RC1012; Allogeneic DNTs RC1012; Allo-DNTs RC1012; Allogeneic Double-negative T-cells RC1012;
NCIt definition : A population of off-the-shelf (OTS) healthy, donor-derived CD4 and CD8 double-negative
T-lymphocytes (allo-DNTs), with potential immunomodulating and anti-leukemic activities.
The DNTs are expanded ex vivo in order to enhance their tumor destroying potential.
Upon administration of the allo-DNTs RC1012, the receptor type II integral membrane
protein (KLRK1; NKG2D) and DNAX accessory molecule 1 (cluster of differentiation 226;
CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed
on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby
destroying the tumor cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like
receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like
domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell
killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on
their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis.;
Molecule name : RC 1012; RC-1012;
NCI Metathesaurus CUI : CL1798550;
Origin ID : C189910;
UMLS CUI : C5706560;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
