Preferred Label : KRAS G12C Inhibitor RMC-6291;
NCIt synonyms : KRAS-G12C(ON) Inhibitor RMC-6291; KRAS G12C(ON) Inhibitor RMC-6291;
NCIt definition : An orally bioavailable, covalent inhibitor of the active, guanosine triphosphate (GTP)-bound
form of the oncogenic KRAS substitution mutation G12C, KRAS G12C(ON), with potential
antineoplastic activity. Upon oral administration, KRAS G12C inhibitor RMC-6291 forms
a tri-complex with the intracellular chaperone protein and immunophilin cyclophilin
A (CypA) and KRAS G12C(ON). This tri-complex inhibits KRAS G12C(ON)-mediated signaling,
which may inhibit tumor cell proliferation. KRAS, a member of the RAS family of oncogenes,
serves an important role in cell signaling, division and differentiation. Mutations
of KRAS may induce constitutive signal transduction leading to tumor cell growth,
proliferation, invasion, and metastasis.;
Molecule name : RMC-6291; RMC 6291;
NCI Metathesaurus CUI : CL1798653;
Origin ID : C189824;
UMLS CUI : C5706556;
Semantic type(s)
- concept_is_in_subset
- has_target
