Preferred Label : Engineered IL-2 Prodrug WTX-124;
NCIt synonyms : IL-2 INDUKINE Protein WTX-124;
NCIt definition : An engineered, prodrug form of the human endogenous cytokine interleukin-2 (IL-2),
composed of IL-2 linked to an inactivation domain via a tumor protease-sensitive linker,
and a half-life extension domain, with potential immunoregulatory and antineoplastic
activities. Upon administration of engineered IL-2 prodrug WTX-124, IL-2 is bound
to the inactivation domain and pharmacologically inactive. Upon proteolytic cleavage
in the tumor microenvironment (TME), active IL-2 is released. IL-2 binds to the high-affinity
IL-2 receptors expressed on CD8 T-cells and natural killer (NK) cells, thereby activating
IL2R-mediated signaling. The activation and expansion of CD8 T-cells and NK cells
mediate cytolytic immune responses against tumor cells, which kills tumor cells and
inhibits tumor cell proliferation. The selective activation in the TME enhances the
IL-2-mediated cytolytic responses against tumor cells while sparing the unwanted effects
of systemic, peripheral immune activation. The inclusion of the half-life extension
domain prolongs the agent's exposure in the tumor.;
Molecule name : WTX-124; WTX 124;
NCI Metathesaurus CUI : CL1798649;
Origin ID : C189820;
UMLS CUI : C5706552;
Semantic type(s)
- concept_is_in_subset
