Preferred Label : Precemtabart Tocentecan;
NCIt synonyms : Anti-CEA ADC M9140; Anti-CEA Antibody-drug Conjugate M9140; Anti-CEACAM5 ADC M9140; Anti-CEACAM5 Antibody-drug Conjugate M9140;
NCIt definition : An antibody-drug conjugate (ADC) composed of precemtabart, a human immunoglobulin
G1-kappa monoclonal antibody directed against the tumor-associated antigen (TAA) carcinoembryonic
antigen-related cell adhesion molecule 5 (CEACAM5; CEA), conjugated with tocentecan,
which consists of a linker and the cytotoxic agent and camptothecin analog exatecan,
with potential antineoplastic activity. Upon administration of precemtabart tocentecan,
the precemtabart moiety targets and binds to CEACAM5 expressed on tumor cells. Upon
binding and internalization, exatecan is released and inhibits DNA topoisomerase I
activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and
apoptosis in CEACAM5-expressing tumor cells. CEACAM5, a member of the CEA family of
proteins that plays a key role in cell migration, cell invasion, and cell adhesion,
is overexpressed by a variety of cancer cell types.;
UNII : V97BV45YBZ;
CAS number : 2873366-83-5;
Molecule name : M-9140; M 9140;
NCI Metathesaurus CUI : CL1798646;
Origin ID : C189819;
UMLS CUI : C5706551;
Semantic type(s)
- concept_is_in_subset
- has_target
