Preferred Label : Anti-CEACAM5 Antibody-drug Conjugate M9140;
NCIt synonyms : Anti-CEA ADC M9140; Anti-CEA Antibody-drug Conjugate M9140; Anti-CEACAM5 ADC M9140;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion
molecule 5 (CEACAM5; CEA), linked to the cytotoxic agent and camptothecin analog exatecan,
with potential antineoplastic activity. Upon administration of anti-CEACAM5 ADC M9140,
the anti-CEACAM5 monoclonal antibody moiety targets and binds to CEACAM5 expressed
on tumor cells. Upon binding and internalization, exatecan is released and inhibits
DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in
cell cycle arrest and apoptosis in CEACAM5-expressing tumor cells. CEACAM5, a member
of the CEA family of proteins that plays a key role in cell migration, cell invasion,
and cell adhesion, is overexpressed by a variety of cancer cell types.;
Molecule name : M-9140; M 9140;
NCI Metathesaurus CUI : CL1798646;
Origin ID : C189819;
UMLS CUI : C5706551;
Semantic type(s)
- concept_is_in_subset
- has_target
