Preferred Label : Anti-GARP Monoclonal Antibody HLX60;
NCIt synonyms : Anti-glycoprotein A Repetitions Predominant Monoclonal Antibody HLX60;
NCIt definition : A monoclonal antibody directed against the transforming growth factor beta (TGFbeta)
activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing
protein 32; LRRC32), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-GARP monoclonal antibody HLX60 selectively targets and binds
to GARP. This specifically blocks the GARP-mediated release of the cytokine transforming
growth factor-beta 1 (TGF-b1), thereby relieving the immunosuppression caused by TGF-b1,
reversing the immunosuppressive nature in the tumor microenvironment (TME), and improving
anti-tumor immune responses. In addition, HLX60 induces antibody dependent cell-mediated
cytotoxicity (ADCC), which leads to a depletion of GARP-positive tumor cells and immunosuppressive
regulatory T-cells (Tregs). The depletion of Tregs further leads to a reversal of
immunosuppression mediated by GARP-positive Tregs and enhances the immune response
to tumor cells. GARP, a transmembrane protein highly expressed on activated, immunosuppressive
Tregs in the TME, is essential for the expression of TGF-b1 on the cell surface of
activated Tregs; it plays an important role in regulation of the immune cell function
and the immunosuppressive nature of Tregs.;
Molecule name : HLX 60; HLX-60;
NCI Metathesaurus CUI : CL1798641;
Origin ID : C189812;
UMLS CUI : C5706548;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
