NCIt definition : Associated with hepatocellular carcinomas, Peroxisome Proliferation occurs in epigenetic
non-genotoxic responses of hepatocytes to diverse peroxisome proliferator chemicals
and involves, probably by a steroid superfamily receptor-based mechanism (PPARs),
altered expression of cellular growth and/or differentiation genes, induction of peroxisomal
enzymes, and possibly oxidative stress.;