Preferred Label : Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115;
NCIt synonyms : bIL15-expressing TILs OBX-115; CytoTIL15; IL15-engineered TILs OBX-115; IL-15-engineered tumor-infiltrating lymphocytes OBX-115; IL-15-engineered TILs OBX-115;
NCIt definition : A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically
engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating
and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115,
the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required
for the maintenance of long-lived CD8 memory T-cells. Sustained IL-15 signaling enhances
TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the
need for concomitant administration of systemic IL-2 which is needed to improve the
efficacy of conventional TILs.;
Molecule name : OBX 115; OBX-115;
NCI Metathesaurus CUI : CL1794286;
Origin ID : C189093;
UMLS CUI : C5706539;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
