Preferred Label : Oncogene Activation Process;
NCIt synonyms : Oncogene Activation;
NCIt definition : Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss
of regulation of the gene product, and predisposing the cell to neoplastic transformation.
Proto-oncogenes are ordinarilly involved in transduction of signals that regulate
cell growth and differentiation. Activation of such genes overrides the normal mechanisms
of regulation and is an important step in the process of cellular transformation.;
NCIt note : Gain of function mutations in proto-oncogenes generally act in a dominant fashion,
meaning that only a single copy of the DNA sequence alteration is necessary for the
step along the path to transformation.;
Origin ID : C18909;
UMLS CUI : C1518575;
Semantic type(s)
- biological_process_is_part_of_process
