Preferred Label : Gallium Ga 68-labeled Tilmanocept;
NCIt synonyms : Gallium-68-tilmanocept; 68Ga-tilmanocept; Gallium Ga 68-labeled DTPA-Mannosyl-Dextran; Gallium Ga 68-labeled Diethylenetriamine Pentaacetic Acid-Mannosyl-Dextran;
NCIt definition : A radioconjugate composed of tilmanocept, a macromolecule consisting of multiple units
of mannose and the chelating agent diethylenetriaminepentaacetic acid (DTPA) each
covalently attached to a 10 kDa dextran backbone, labeled with the radioisotope gallium
Ga 68, with potential use as a tracer for cancer sentinel lymph node (SLN) upon positron
emission tomography (PET)/computed tomography (CT). Upon administration, the mannose
moiety of gallium Ga 68-labeled tilmanocept selectively binds to macrophage mannose
receptor 1 (mannose receptor; MR; CD206) expressed on the surface of macrophages and
dendritic cells (DCs) in lymphatic tissue. Upon PET/CT imaging, SLN may be imaged
and mapped. Tilmanocept exhibits rapid clearance from the injection site, rapid uptake
and high retention within the first draining lymph node, and low uptake by the remaining
lymph nodes. CD206, a member of the C-type lectin (CLEC) family that binds mannose
or fucose carbohydrate residues, such as those found on the surfaces of many pathogens,
is expressed on the surface of macrophages and DCs in lymphatic tissue.;
NCI Metathesaurus CUI : CL1794296;
Origin ID : C189079;
UMLS CUI : C5708226;
Semantic type(s)
- concept_is_in_subset
