Preferred Label : Anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes;
NCIt synonyms : Anti-CD38-CAR-CD3z/4-1BB-expressing T-lymphocytes;
NCIt definition : A preparation of genetically modified T-lymphocytes that have been transduced with
a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the
tumor-associated antigen (TAA) cluster of differentiation 38 (CD38) that is linked
to tandem costimulatory domains of the zeta chain of the T-cell receptor (TCR)/CD3
complex (CD3z) and 4-1BB (CD137), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes
are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38,
a type II transmembrane glycoprotein, is present on various immune cells and hematologic
malignancies, and its expression has been correlated with poor prognosis.;
NCI Metathesaurus CUI : CL1794275;
Origin ID : C189049;
UMLS CUI : C5708216;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
