Preferred Label : Immune Effector Cell Associated Neurotoxicity Syndrome Grade 4;
NCIt synonyms : ICANS Grade 4;
NCIt definition : Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an
immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE
scale cannot be performed (for adults and children over 12), or if the Cornell Assessment
of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under),
the inability of the affected individual to be arousable without vigorous or repetitive
tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or
repetitive clinical or electroencephalographically-detected seizures without ever
returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on
neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema
or Cushing's triad (bradycardia, hypertension, respiratory depression).;
NCI Metathesaurus CUI : CL1764808;
Origin ID : C188940;
UMLS CUI : C5539146;
Has associated anatomic sites
- Semantic type(s)
- disease_has_finding
