Preferred Label : Engineered Red Blood Cells Expressing 4-1BBL/IL-12 RTX-224;
NCIt synonyms : Engineered RBCs Expressing 4-1BBL/IL-12 RTX-224;
NCIt definition : An off-the-shelf (OTS) preparation of allogeneic red blood cells (RBCs) genetically
engineered with a lentiviral vector to express on the cell surface the co-stimulatory
molecule tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL)
and the immunostimulatory cytokine interleukin-12 (IL-12), with potential immunomodulating
and antineoplastic activities. Upon administration of the engineered RBCs expressing
4-1BBL/IL-12 RTX-224, 4-1BBL and IL-12 expressed on these cells bind to 4-1BB and
IL-12 receptors. This induces the proliferation and activation of CD4- and CD8-positive
T-cells and natural killer (NK) cells, which induces the production of inflammatory
cytokines and chemokines, and leads to the activation of antigen-presenting cells
(APCs) and enhanced antigen presentation. Altogether, this activates both the adaptive
and innate immune system and leads to the induction of anti-tumor immune responses,
thereby killing the tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis
factor receptor superfamily (TNFRSF), is an inducible costimulatory receptor that
plays a key role in T-cell proliferation, survival and cytolytic activity. IL-12 promotes
the activation of NK cells.;
Molecule name : RTX-224; RTX 224;
NCI Metathesaurus CUI : CL1794044;
Origin ID : C188894;
UMLS CUI : C5706516;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
