Preferred Label : Anti-B7-H3 Antibody-drug Conjugate YL201;
NCIt synonyms : ADC YL201; Anti-B7-H3 ADC YL201;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) site-specifically conjugated
to an as of yet undisclosed topoisomerase-1 inhibitor via a tumor protease-cleavable
linker, with potential antineoplastic activity. Upon administration of anti-B7-H3
ADC YL201, the antibody moiety targets and binds to B7-H3-expressing tumor cells.
Upon binding, internalization and linker cleavage, the topoisomerase-1 inhibitor is
released and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and apoptosis in tumor cells expressing B7-H3.
B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein
superfamily, is overexpressed on certain tumor cell types and on various immune cells.
It is a negative regulator of T-cell activation, and its overexpression plays a key
role in tumor cell invasion and metastasis.;
Molecule name : YL-201; YL 201;
NCI Metathesaurus CUI : CL1794071;
Origin ID : C188794;
UMLS CUI : C5706511;
Semantic type(s)
- concept_is_in_subset
- has_target
