Preferred Label : Oncolytic RNA Virus IVX037;
NCIt synonyms : Oncolytic Virus IVX037;
NCIt definition : A receptor-targeted oncolytic RNA virus, with potential antineoplastic and immunomodulating
activities. Upon intra-tumoral administration, the oncolytic RNA virus IVX037 selectively
targets specific receptors overexpressed on cancer cells, thereby allowing for selective
replication in cancer cells without being able to infect and replicate in normal,
healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer
cells, which leads to cancer cell lysis. Following the lysis of infected cells, the
replicated virus is released and can infect adjacent tumor cells, which both induces
further tumor cell oncolysis and may beneficially alter the tumor microenvironment
(TME). This may further activate both innate and adaptive immune responses against
cancer cells.;
Molecule name : IVX 037; IVX-037;
NCI Metathesaurus CUI : CL1794072;
Origin ID : C188793;
UMLS CUI : C5706510;
Semantic type(s)
- concept_is_in_subset
