Lung Small Cell Carcinoma, Neuroendocrine-High Subtype

Preferred Label : Lung Small Cell Carcinoma, Neuroendocrine-High Subtype;

NCIt synonyms : Lung Small Cell Carcinoma, NE-High Subtype; SCLC, NE-High Subtype;

NCIt definition : Lung small cell carcinoma characterized by high expression pattern of different neuroendocrine markers such as chromogranin A, synaptophysin, neural cell adhesion molecule 1, and gastrin-releasing peptide. It is associated with low numbers of infiltrating immune cells (immune desert phenotype).;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1793706;

Details

Origin ID

C188754;

UMLS CUI

C5708009;

Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Neuroendocrine Large Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Neuron-Specific Enolase Positive Neoplastic Cells Present [NCIt concept]
- Rosette Formation [NCIt concept]
- Sheet-Like Growth Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Neck [NCIt concept]
Has associated anatomic sites
- Lung [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Premalignant Lesion [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Neuroendocrine Small Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- High Expression Pattern of Neuroendocrine Markers Present [NCIt concept]
- High Grade Lesion [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- More than 10 Mitoses per 10HPF [NCIt concept]
- Necrotic Change [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Nuclear Molding [NCIt concept]
- Peripheral Nuclear Palisading [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bronchus [NCIt concept]
- Lung [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_associated_disease
- Paraneoplastic Syndrome [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 17q [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 20q [NCIt concept]
- Gain of Chromosome 3q [NCIt concept]
- Gain of Chromosome 5p [NCIt concept]
- Gain of Chromosome 6p [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Loss of Chromosome 10q [NCIt concept]
- Loss of Chromosome 17p [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 4 [NCIt concept]
- Loss of Chromosome 5q [NCIt concept]
- del(13q14) [NCIt concept]
disease_may_have_molecular_abnormality
- C-KIT Tyrosine Kinase Protein Overexpression [NCIt concept]
- FGFR1 Gene Amplification [NCIt concept]
- NMYC Gene Amplification [NCIt concept]
- PTEN Gene Mutation [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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