" /> Afeletecan Hydrochloride - CISMeF





Preferred Label : Afeletecan Hydrochloride;

NCIt synonyms : Camptothecin Glycoconjugate BAY 38-3441;

NCIt related terms : BAY 56-3722;

NCIt definition : The hydrochloride salt form of afeletecan, a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called camptothecins.;

UNII : DTJ7VPW43J;

CAS number : 215604-74-3;

Molecule name : BAY 56-3722; BAY 38-3441; BAY56-3722;

Codes from synonyms : CDR0000269412;

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Keyword's position in hierarchy(ies) : arborescence

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08/05/2025


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