" /> Taletrectinib Adipate - CISMeF





Preferred Label : Taletrectinib Adipate;

NCIt definition : The adiptate form of taletrectinib, a n orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, taletrectinib binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression.;

UNII : 6KLL51GNBG;

CAS number : 1505515-69-4;

Drug name : Ibtrozi; Dovbleron;

Molecule name : DS-6051b;

NCI Metathesaurus CUI : CL1793515;

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30/07/2025


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