Preferred Label : Taletrectinib Adipate;
NCIt definition : The adiptate form of taletrectinib, a n orally available inhibitor of the receptor
tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase
(NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration,
taletrectinib binds to and inhibits ROS1 and the NTRK family members. This inhibition
leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits
the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed
in certain cancer cells, plays a key role in cell growth and survival of cancer cells.
NTRK mutations or rearrangements play a key role in cancer progression.;
UNII : 6KLL51GNBG;
CAS number : 1505515-69-4;
Molecule name : DS-6051b;
NCI Metathesaurus CUI : CL1793515;
Origin ID : C188465;
UMLS CUI : C5707797;
Semantic type(s)
- concept_is_in_subset
