Preferred Label : CAR T-cell-Related Hemophagocytic Lymphohistiocytosis-like Syndrome;
NCIt synonyms : carHLH; CAR T-cell-Associated HLH; CAR T-cell-Related HLH-like Syndrome; CAR T-cell-Associated Hemophagocytic Lymphohistiocytosis;
NCIt definition : A group of rare but severe toxicities resembling hemophagocytic lymphohistiocytosis
(HLH) that present in a subset of patients with cytokine release syndrome (CRS) following
chimeric antigen receptor (CAR) T-cell therapy. Characteristic findings may include
hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia, coagulopathy, hepatic
transaminitis, hyperbilirubinemia, neutropenia, elevated lactate dehydrogenase, and
occasionally hemophagocytosis.;
NCI Metathesaurus CUI : CL1793625;
Origin ID : C188397;
UMLS CUI : C5706237;
Semantic type(s)
- concept_is_in_subset
